How to clean therapure tpp100 filter at the bottom of the unit unscrew the filter lock mechanism by turning it counter clockwise remove the inlet grill from the unit inside you should find the hepa type filter remove the hepa type filter from the inlet grill using a vacuum with a brush or . This filter requires a bit of a different cleaning process due to the fact that the shape of this unit is a bit different than the other models that therapure usually makes so even though making sure this unit is clean will be a bit of a procedure once cleaned the model will run and work great. 1 cleaning the therapure tpp50 filter the cleaning process of the tpp50 is a little different compared to the other therapure models because its plugged into an outlet dont worry its still extremely easy to clean the filter you would have to get rid of the tpp50 air purifier from the wall outlet